Bisono® tape is a transdermal patch for the treatment of hypertension containing 4mg or 8mg of bisoprolol with β₁-blocking activity, which is administered once a day for 24 hours applied to the chest, upper arm or back.
The features of Bisono® tape are as follows:
In Phase III studies, Bisono® tape demonstrated sufficient continuous antihypertensive effects over a period of 24 hours in Japanese patients suffering from mild to moderate essential hypertension. The frequencies of side effects of Bisono® tape were similar to those of other oral β₁–blockers except those on the administration site.
*: β₁-blockers are a group of drugs that can selectively block β₁-receptors of the adrenergic receptors in the sympathetic nervous system, typically expressed on heart and kidney. β₁-blockers cause demonstrate antihypertensive effect by decreasing cardiac output, suppressing norepinephrine release from the sympathetic nerve terminals and/or suppressing renin release from the juxtaglomerular cells.
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