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Pharmaceutical products/Transdermal drug delivery patches

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Transdermal drug delivery: a new medication system delivers a drug into the body through the skin.
Transdermal drug delivery: a new medication system delivers drug into the body through the skin. A system that offers many advantages over conventional injection and oral methods: it reduces the load that the oral route commonly places on the digestive tract and liver; and there is no pain from a syringe. What’s more, by controlling the dosage, it allays the patient’s fears and minimizes harmful side effects of a drug caused from temporary overdose; it ensures therapeutic effects as the durability of response lasts long and increases patient compliance by providing visual confirmation of medication (application). Since the late 1970s, Nitto Denko has taken a leading position in the development of transdermal drug delivery patches by developing technologies for the design of safe, stable transdermal patches and the synthesis of optimal adhesives in order to ensure prescribed rates of drug release. We remain committed to improving quality of life by introducing a variety of transdermal systems for new areas of treatment.

Transdermal patch for ischemic heart disease
This transdermal patch of isosorbide dinitrate in a viscoelastic polymer matrix is used for treatment of angina pectoris and other ischemic heart diseases. When applied to the chest or upper abdomen, the patch releases the drug through our proprietary crystal-reservoir system, thereby contributing to stable improvement of cardiac functioning. The patch, which employs our lipo-gel adhesive to minimize skin irritation, has earned an excellent reputation as a gentle, easy-to-use, and "wearable" cardiac remedy.

Transdermal patch for asthma
It is the world's first adhesive patch formulation that contains tulobuterol usually used for treating asthma. Generally, it is known that there is a rhythm in respiratory function, which declines from midnight to early morning. This product is perfect for such condition from chronopharmacotherapy point of view, i.e., "take medicine when you need with the amount you need" along with the rhythm of bodily function.

Path for local anesthesia
This transdermal patch contains lidocaine, which is usually used to anesthetize skin, and relieves the pain experienced on insertion of large needles, such as the indwelling needles used in hemodialysis. The pain from such needles increases fear and distress and clearly reduces the medical benefits. Nitto Denko's drug-delivery technology, however, introduces a "painless puncture" that delivers a local anesthetic into the skin at a high concentration.

Development of the transdermal drug delivery patch
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A physician’s prescription is needed to use these pharmaceutical products.



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